Lecturer;Master’s supervisor

Address：College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450002

E-mail:peixiaodong@zzuli.edu.cn

Research Field and Interests：

[1]Design andfunctionalenhancement ofbiocatalysts

[2]Proteinbiocatalysis andtransformation

Education Background：

[1]2013-2017,Henan Agricultural University, Bachelor’s Degree

[2]2017-2020,Guangxi University, Master’s Degre

[3]2020-2024,Guangxi University, Ph.D.

Publications：

[1]Pei XD, Wu BH, Zhang C, Liu M, Zheng XY, Zhang Can, Zhang Xu, Wang WJ, Yang X, Wei T*, Zhang X*. Biological detoxification of gossypol: Enzymatic mechanisms, system engineering, and prospects for green valorization [J].Journal of Agricultural and Food Chemistry.2026.https://doi.org/10.1021/acs.jafc.5c17645. (JCR Q1,IF 6.2)

[2]Pei XD, Zheng XY, Zhang C, Tan FJ, Yang X, Zhang ZP, Zhang F, Zhang X*, Wei T*. Recent Advances in Phospholipase C Applications in Food Industry: From Molecular Mechanisms to Green Processing Technologies [J].Journal of Agricultural and Food Chemistry. 2025, 73, 50, 31680-31699.https://doi.org/10.1021/acs.jafc.5c11096.(JCR Q1,IF 6.2)

[3]Pei XD, Jiao DQ, Zhou ZQ, He YN, Chen GG, Zhang C, Zheng XY, Yang X, Wei T*, Wang CH*. Revolutionizing keratinase science: Biocatalytic advances, sustainable innovation, and industrial perspectives[J].Biotechnology Advances. 2025, 83,108657.https://doi.org/10.1016/j.biotechadv.2025.108657.(JCR Q1,IF 12.5)

[4]Pei XD, Jiao DQ, Li F,Fang YH,Zhou ZQ, Liu XL, Wang CH*.Targeted Adherence and Enhanced Degradation of Feather Keratins by a Novel Prepeptidase C-Terminal Domain-Fused Keratinase[J].Journal of Agricultural and Food Chemistry. 2025, 73,2, 1182-1192. https://doi.org/10.1021/acs.jafc.4c09667.(JCR Q1,IF 6.2)

[5]Pei XD, Fan HL, Jiao DQ, Li F, He YN, Wu QL, Liu XL, Wang CH*. Rational engineering S1' substrate binding pocket to enhance substrate specificity and catalytic activity of thermal-stable keratinase for efficient keratin degradation [J].International Journal of Biological Macromolecules. 2024, 263, PartA, 130688. https://doi.org/10.1016/j.ijbiomac.2024.130688. (JCR Q1,IF8.2)

[6]Pei XD, He YN, Wu QL,Zhang, YM, Li F, Jiao DQ,Liu XL, Wang CH*. Novel Antioxidant Peptides Derived from Feather Keratin Alleviate H₂O₂-Induced Oxidative Damage in HepG2 Cells via Keap1/Nrf2 Pathway[J].Journal of Agricultural and Food Chemistry. 2023, 71, 50, 20062–20072. https://doi.org/10.1021/acs.jafc.3c05088. (JCR Q1,IF6.1)

[7]Pei XD, Li F, Zhang YM, Huang XN, Yu FT, Su LY, Liu XL, Wang CH*. Preparation, Purification, and Identification of Novel Feather Keratin-Derived Peptides with Antioxidative and Xanthine Oxidase Inhibitory Activities.Journal of Agricultural and Food Chemistry. 2023, 71, 21, 8061–8070. https://doi.org/10.1021/acs.jafc.3c01131. (JCR Q1,IF6.1)

[8]Pei XD, Li F, Gao TT, Su LY, Yu FT, Shi P, Liu CX, Wang CH*. Utilization of feather keratin waste to antioxidant and migration-enhancer peptides byBacillus licheniformis 8-4.Journal of Applied Microbiology. 2023, 134(2): lxad005. https://doi.org/10.1093/jambio/lxad005. (JCR Q2, IF4.0)

[9]Pei XD, Li F, Yue SY, Huang XN, Gao TT, Jiao DQ, Wang CH*. Production and characterization of novel thermo- and organic solvent-stable keratinase and aminopeptidase fromPseudomonas aeruginosa 4-3 for effective poultry feather degradation.Environmental Science and Pollution Research. 2023, 30 (2):2480-2493. https://doi.org/10.1007/s11356-022-22367-4. (JCR Q1,IF5.8)

[10]Pei XD, Lu LH, Yue SY, Li Y, Liu XL, Li F, Wu KJ, Wang CH*. Characterization of a Novel Shewanella algae Arginine Decarboxylase Expressed inEscherichia coli.Molecular Biotechnology. 2022. 64(1):57-65. https://doi.org/10.1007/s12033-021-00397-6. (JCR Q3,IF2.6)

[11]Pei XD, He ZL, Yao HL, Xiao JS, Li L, Gu JZ, Shi PZ, Wang JH, Jiang LH* (Corresponding author).6-shogaol from ginger shows anti-tumor effect in cervical carcinoma via PI3K/Akt/mTOR pathway.European Journal of Nutrition, 2021, 60(5):2781-2793. https://doi.org/10.1007/s00394-020-02440-9. (JCR Q2,IF5.0)

[12]Pei XD, Yao HL, Shen LQ, Yang Y, Lu L, Xiao JS, Wang XY, He ZL, Jiang LH* (Corresponding author). α-Cyperone inhibits human cervical cancer HeLa cells proliferation via ROS-mediated PI3K/Akt/mTOR signaling pathway.EuropeanJournal of Pharmacology. 2020,883:173355.https://doi.org/10.1016/j.ejphar.2020.173355. (JCR Q1,IF5.0)

[13]Pei XD, Song qing He, Jing chen Wei, Xue sheng Li, Yan yan Wei, Yumeng Zhang, Xinyu Wang, Feng Lin, Zhi long He, LiheJiang*.14,15 beta-dihydroxyklaineanone inhibits HepG2cell proliferation and migration through p38MAPK pathway.Journal of Pharmacy and Pharmacology. 2020,72:1165-1175. https://doi.org/10.1111/jphp.13289. (JCR Q3, IF3.7)

[14]Pei XD, Junsong Xiao, Guijiang Wei, Yumeng Zhang, Feng Lin, Zhao chengXiong, Lan Lu, Xueli Wang, Guangfu Pang, Yan Jiang, Lihe Jiang* (Corresponding author). Oenothein B inhibits human non-small cell lung cancer A549 cell proliferation by ROS-mediated PI3K/Akt/NF-κB signaling pathway.Chemico-Biological Interactions. 2019, 298:112-120. https://doi.org/10.1016/j.cbi.2018.09.021. (JCR Q1, IF5.1)

Patents

[1]Xiao-Dong Pei,Chen Zhang,Xu Yang,Tao Wei. A cottonseed protein source ACE inhibitory peptide and its screening and modification method.April 2026. China, 202610429867.1.

[2]Cheng-Hua Wang,Xiao-Dong Pei, Dao-Quan Jiao, Fan Li, Yi-Ning He. A Keratinase Mutant Derived fromPseudomonas aeruginosa 4-3 and Its Applications. March 2024. China, CN118126990A.

[3]Cheng-Hua Wang,Xiao-Dong Pei, Dao-Quan Jiao, Zhi Zhou, Fan Li. A Truncated E423-PPC1 and Its Applications. June 2024. China, CN118546914A.

Projects：

[1]Research on the Adsorption-Desorption Equilibrium Regulation and Catalytic Enhancement Mechanism of Novel Substrate-Targeting Keratinase (National Postdoctoral Researcher Program C-Class Funding GZC20251965, 2026/01-2027/12,Principal Investigator)

[2]Construction and Synergistic Mechanism Research of Multi-Enzyme Complex for Targeted Degradation of Feather Keratin (China Postdoctoral Science Foundation General Project 2024M763021, 2024/07-2026/08,Principal Investigator)

[3]Research on Molecular Evolution and Engineering of Keratinase Based on Ancestral Sequence Reconstruction (Key Scientific Research Project of Henan Province Higher Education Institutions 26A550029, 2026/01-2027/12,Principal Investigator)

[4]Research on Engineering of Keratinase Based on Ancestral Sequence Reconstruction and Its Application in Feed Processing (National College Students' Innovation and Entrepreneurship Training Program Project 202510462021, 2025.05-2026.05,Advisor)

[5]Study on the Anti-Hepatocarcinoma Mechanism of 14,15-Dihydroxyklaineanone fromEurycoma longifolia Extract (Graduate Education Innovation Project of Guangxi Zhuang Autonomous Region, YCSW2019041, March 2019- November 2020,Principal Investigator, Completed).