Associate Professor; Masters’sSupervisor

ADDRESS：

No. 136, Kexue Avenue, Gaoxin District, Zhengzhou University of Light Industry, 450001, Zhengzhou, China

E-mail：nierongzu@zzuli.edu.cn

Websites：

https://sgxy.zzuli.edu.cn/2024/0418/c18401a310727/page.htm

Research Field and Interests：

TheInteraction between Dietary Bioactive Compounds and Health, Natural Products Chemistry, and Computational Biology

Education Background：

[1]2013-09 to 2018-06, Huazhong Agricultural University, Food Science, Doctor’s Degree

[2]2009-09 to 2013-07, Guangxi University, Food Science and Engineering, Bachelor’s Degree

Teaching Courses：

Food Chemistry;Fundamental Experiments in Food Science;IEC-Food Sensory Evaluation

Publications：

[1] Rongzu Nie, et al. The inhibitory mechanisms of PGG, a natural polyphenol enriched with gallate moieties, against Aβ42 amyloid aggregation: A unified experimental and molecular dynamics simulation study. Bioorganic & Medicinal Chemistry, 136 (2026) 118584.

[2] Rongzu Nie, et al. Notch signaling pathway modulation by food functional ingredients: mechanisms, cancer and immunoregulation. Frontiers in Cell and Developmental Biology, 13 (2025) 1729265.

[3] Rongzu Nie, et al. Interaction between Notch signaling pathway and bioactive compounds and its intervention on cancer. Frontiers in Nutrition, 12 (2025) 1647661.

[4] Rongzu Nie, et al. The role of notch signaling pathway and non-coding RNAs in cancer and inflammation: progress, therapeutic insights, and future directions. Frontiers in Immunology, 16 (2025) 1567040.

[5] Rongzu Nie, et al. Food Functional Factors in Alzheimer’s Disease Intervention: Current Research Progress. Nutrients, 16 (2024) 3998.

[6] Rongzu Nie, et al. Molecular insights into the interactions of theaflavin and epicatechin with different lipid bilayer membranes by molecular dynamics simulation. Chemistry and Physics of Lipids, 262 (2024) 105405.

[7] Rongzu Nie, et al. Molecular insights into the structure destabilization effects of ECG and EC on the Aβ protofilament: An all-atom molecular dynamics simulation study. International Journal of Biological Macromolecules, 253 (2023) 127002.

[8] Rongzu Nie, et al. Molecular insights into the very early steps of Aβ1-42 pentameric protofibril disassembly by PGG: A molecular dynamics simulation study. Journal of Molecular Liquids, 361 (2022) 119638.

[9] Rongzu Nie, et al. Interactions of chlorogenic acid and isochlorogenic acid A with model lipid bilayer membranes: Insights from molecular dynamics simulations. Chemistry and Physics of Lipids, 240 (2021) 105136.

[10] Rongzu Nie, et al. Influence of the gallate moiety on the interactions between green tea polyphenols and lipid membranes elucidated by molecular dynamics simulations. Biophysical Chemistry, 274 (2021) 106592.

[11] Rongzu Nie, et al. Molecular insights into the inhibitory mechanisms of gallate moiety on the Aβ1–40 amyloid aggregation: A molecular dynamics simulation study. International Journal of Biological Macromolecules, 156 (2020) 40-50.

[12] Rongzu Nie, et al. A-type EGCG dimer, a new proanthocyanidins dimer from persimmon fruits, interacts with the amino acid residues of Aβ40 which possessed high aggregation-propensity and strongly inhibits its amyloid fibrils formation. Journal of Functional Foods, 52 (2019) 492-504.

[13] Rongzu Nie, et al. Comparison of disaggregative effect of A-type EGCG dimer and EGCG monomer on the preformed bovine insulin amyloid fibrils. Biophysical chemistry, 230 (2017) 1-9.

[14] Rongzu Nie, et al. A-type dimeric epigallocatechin-3-gallate (EGCG) is a more potent inhibitor against the formation of insulin amyloid fibril than EGCG monomer. Biochimie, 125 (2016) 204-212.

Projects：

[1] Natural Science Foundation of Henan: Molecular Mechanism Study of β-PGG and Its Structural Analogs Inhibiting the Amyloid Aggregation of Aβ42 Peptide, a Key Molecule in Alzheimer's Disease (Project No.: 252300421733), Principal Investigator;

[2] Key Scientific and Technological Project of Henan Province: Preparation of Novel Amyloid Fibril-Polyphenol Antibacterial Hydrogel and Its Application in Fresh Prepared Beef (Project No.: 242102110106), Principal Investigator;

[3] Key Scientific Research Projects of Colleges and Universities in Henan Province: Experimental and Molecular Dynamics Simulation Study on the Molecular Mechanism of Theaflavins Inhibiting Amyloid Aggregation of Aβ Peptide (Project No.: 24A550019), Principal Investigator;