Xuepeng Yang

Prof. PhD supervisor, master supervisor

ADDRESS：No.163 Kexue Road, Zhengzhou, Henan Province, China

PHONE：0371-86608262

E-mail：yangxuepen@zzuli.edu.cn

Research Interests:

Biocatalysis and transformation: Focus on the research of the biosynthesis mechanism and technology for high-value chemicals (biomedicine, fine chemicals, functional food). Improving tobacco quality, reduce harmful substances, synthesize essential tobacco flavor substances and comprehensively utilize tobacco resources using biotechnology.

Education Background:

2016/9-2017/9, St.andrews University, UK, School of Chemistry, Visiting Scholar, Supervisor Professor Jame H.Naismith, Academician of the Royal Academy of Sciences

2011/9-2013/9, Auburn University, USA, Postdoctoral fellow in the Department of Chemistry and Biochemistry, Supervisor Professor Steven Mansoorabadi

2004/9-2008/2, East China University of Science and Technology, State Key Laboratory of Bioreactors, Biochemical Engineering, Ph.D./Ph.D. Supervisor Prof. Wei Dongzhi

2001/9-2004/6, China Agricultural University and Institute of Microbiology, Chinese Academy of Sciences, State Key Laboratory of Resources, Joint Cultivation, Food Science, Master's Degree/Master's Degree, Supervisor Jin Cheng, Professor Han Beizhong

1993/9-1997/6, Zhengzhou Institute of Light Industry, Fermentation Engineering, Bachelor Degree/Bachelor Degree

Courses Offered:

Biochemistry, Enzyme Engineering, Biology English; Special Topics in Biocatalysis and Transformation (Graduate Course)

Publications:

Yulu Miao, Hui Ni, Xingyi Zhang, Fengdong Zhi, Xiang Long, Xuepeng Yang#, Xiao He, Lujia Zhang. Investigating mechanism of sweetness intensity differences through dynamic analysis of sweetener-T1R2-membrane systems. Food Chemistry, 2022, 374:131807 JCR1, TOP，IF4.53 （NSFC）

Yue Zhao, Yulu Miao,Fengdong Zhi, Yue Pan, Jianguo Zhang, Xuepeng Yang#, John Z.H.Zhang,Lujia Zhang. Rational design of pepsin for enhanced thermostability via exploiting the guide of structural weakness of stability. Frontiers in Physics, 2021, 10.3389/fphy.2021.755253

JianBin Ye, Yilang Ding,Xiaona Qi, Jia Xu, Xuepeng Yang#, Zhan Zhang. Geographic and position-based variations in phyllospheric bacterial communities present on flue-cured tobacco. Applied Microbiology and Biotechnology,2021,105(24):9297-9308

Ke Ma, Zhen-zhen Wu,Guang-Lu Wang, Xuepeng Yang#.Separation and purification of pyrroloquinoline quinine from Gluconobacter oxydans fermentation broth using supramolecular solvent complex extraction. Food Chemistry, 2021,361:130067 JCR1, TOP，IF4.53 （NSFC）

Guang Lu Wang, Yi-fei Zhou, Fan Zhang, Jian-bin Ye, Gui-fang Zhong, Xuepeng Yang#. Bioconversion of recombinantly produced precursor peptide pqqA into pyrroloquinoline quinine using a cell-free in vitro system. Protein Expression and Purification. 2020,178:105777

Jianbin Ye, Shanshan Zheng, Zhan Zhang, Feng Yang, Ke Ma, Yinjie Feng, Jianqiang Zheng, Duobin Mao, Xuepeng Yang#. Bacterial cellulose production by Acetobacter xylinum ATCC 23767 usingtobacco waste extract as culture medium. Bioresource Technology. 2019, (274) 518-524. (IF=5.807, JCR1)

Ke Ma, Junzhu Cui, Jianbin Ye, Xianmei Hu, Geli Ma, Xuepeng Yang#. Pyrroloquinoline quinone from Gluconobacter oxydans fermentation broth enhances superoxide anion-scavenging capacity of Cu/Zn-SOD. Food Chemistry, 2017, 230:291-294, JCR1, TOP，IF4.53 （NSFC）

Jianbin Ye, Ji Yan, Zhan Zhang, et al, Xuepeng Yang#. The effects of threshing and redrying on bacterial communities that inhabit the surface of tobacco leaves. Applied Microbiology and Biotechnology. 2017, 101(10):4279-4287 JCR2, TOP IF3.4

Jianbin Ye, Ji Yan, Jia Xu, Ke Ma, Xuepeng Yang#. Zoonotic Enterocytozoon bieneusi in raw wastewater in Zhengzhou, China. Folia Parasitol, 2017, 64: 002. (IF=1.2, JCR 2)

Guifang Zhong, Fangfang Wang, Jianhong Sun, Xuepeng Yang#. Bioconversion of lutein by Enterobacter hormaechei to form a new compound, 8-methyl-α-ionone. Biotechnol. Letters, 2017, 39(7):1019-1024 IF1.85 （NSFC）

Xue Peng Yang, Ke Ma, Xian Mei Hu, Jian Bin Ye, Yin Lin. A new monoterpenoid indole alkaloid from Tabernaemontana corymbosa. Chemistry of Natural Compounds, 2016, 2:1-3 IF 0.46 （NSFC）

Xuepeng Yang, Ji Yan, Fangfang Wang, et al, Comparison of organics and heavy metals acute toxicities to Vibrio fischeri. Journal of the Serbian Chemical Society. 2016, 81:697-705 IF0.82

Yang Xue-Peng, Wang Fang-Fang, Yan Ji, Ma Ke, Mao Buo-Bin. A new family-3 glycoside hydrolase from Penicillium oxalicum BL 3005 catalyzing tyrosol glucosylation to form salidroside. Biotechnology and Applied Biochemistry. 2016, 64:525-531 IF 1.4 （NSFC）

Zheng Kaiyuan, Phong D. Ngo, Victoria L. Owens, Yang Xuepeng, Steven O. Mansoorabadi. The biosynthetic pathway of coenzyme F430 in methanogentic and methanotrophic archaea. Science, 2016, 354 (6310): 339-342 TOP

Yang XuePeng, Li PanPan, Hu XianMei, Ye JianBin, Liu Yin, Ma Ke, Mao DuoBin.UPLC-DAD-MS/MS Method for Analysis of PQQ in the Fermentation Broth (2015) Chromatographia, 78(17):1185-1189. SCI,（NSFC）

Yue Zhao, Gui-fang Zhong, Xue-peng Yang*, Xian-mei Hu, Duo-Bin Mao, Yuping Ma.Bioconversion of lutein to form aroma compounds by Pantoea dispersa. Biotechnology Letters, 2015,37:1687-1692

Xuepeng Yang, Panpan Li, Fangfang Wang, Jianbin Ye, Ke Ma, Duobin Mao. An efficient separation of pyrroloquinoline quinone using chemical complexation extraction. Advances in Engineering Research, 2015, 79-82

Yang Xuepeng, Maobing Tu, Sushil Adhikari, Zhaohui Tong. A comparison of three pHcontrol methods for revealing effects of undissociated butyric acid on specific butanolproduction rate in batch fermentation of Clostridium acetobutylicum. 2013, AMB express,3:3-6. SCI, JCR2

Yang Xue-Peng, Zhong G.F., Mao D.B. Pyrroloquinoline quinone biosynthesis in Escherichia coli by expression of the Gluconobacter oxydans pqqABCED gene cluster. Journal of Industrial Microbiology Biotechnology, 2010, 37:575-580. SCI, JCR2

Yang Xue-Peng, Ye J.B., Yin B. Wei D.Z. A Pyrroloquinoline quinone –dependentmembrane-bound D-sorbitol dehydrogenase from Gluconobacter oxydans exhibits an orderedBi Bi reaction mechanism. Archives of Biochemistry and Biophysics. 2008, 477:206-210. SCI, JCR3

Yang Xue-Peng, Wei L.J., Lin J.P., Wei D.Z. Membrane-bound Pyrroloquinoline quinone-dependent Dehydrogenase in Gluconobacter oxydans M5, responsible for productionof 6-(2-hydroxyethyl) Amino-6-deoxy-L-sorbose. Applied and Environmental Microbiology.2008, 74：5250-5253 JCR2, TOP

Pengyong You, Xuepeng Yang, Dongzhi Wei, Erzheng Su. 2011.Carica papaya lipase-catalyzed synthesis of terpene esters,Journal of Molecular Catalysis B: Enzymatic,71(3) :152-158

Wei Liu-Jing Xue-Peng Yang, Hua J., et al. 2010. Characterization of Enzymes in the Oxidation of 1,2-Propanediol to D-Lactic Acid by Gluconobacter oxydans DSM 2003, Molecular biotechnology, 46:26-33.

Guodong Wei, Xuepeng Yang, Lin J., et al. 2009. High cell density fermentation of Gluconobacter oxydans DSM2003 for glycolic acid production. Jounal of Industry Microbology Biotechnology. 36：1029-1034.

Wei Guo-Dong, Yang Xue-Peng, Lin J., et al. 2009. Adsorptive Bioconversion of Ethylene glycol to Glycolic acid by Gluconobacter oxydans DSM 2003. Biochemical Engineering Journal, 47：127-131.

Bo Yin, Xue-peng Yang, Wei Guo-Dong, et al. 2008, Expression of Two Old Yellow Enzyme Homologues from Gluconobacter oxydans and Identification of their Citral Hydrogenation Abilities. Molecular Biotechnology, 38:241-245

Research Projects:

1. Research projects Inline

[1] National Natural Science Foundation of China, Research on the Generation Reaction Mechanism of a Novel Cyclic Cross-linking of Peptide PqqA, Project No. U1904101, Start and End Date, 2020.01-2022.12,600,000;

[2] National Tobacco Monopoly Administration (State Tobacco Corporation) key research and development project, technology development and application of biosynthetic nicotine controlled release materials from waste tobacco, 2022.01-2024.12, 2 million.

[3] National Tobacco Monopoly Administration (State Tobacco Corporation) major research and development project, the second host unit, development of special reconstituted tobacco leaves for heated cigarettes based on tobacco fermented cellulose aroma-carrying materials, 2021.01-2022.12,600,000.

[4] The Organization Department of the CPC Henan Provincial Committee, the Human Resources and Social Security Department of Henan Province, the Central Plains Talent Program, "Central Plains Basic Research Leading Talents", 2020.12, ZYYCYU202012128.100 million.

[5] Zhengzhou City Collaborative Innovation Project, development and application of key technologies for green synthesis of new coenzyme "pyrroloquinoline quinone", 2021.11-2023.11, 300,000.

[6]Enterprise entrusted project, "Pyrroloquinoline quinone" high-efficiency separation and purification process research, Zhengzhou Mingde Biotechnology Co., Ltd., 2018.08.10-2020.08.10, 1 million;

[7] Enterprise-entrusted project, Henan China Tobacco Industry Co., Ltd., Research on Bioselective Degradation of Sterols in Tobacco, 2017.6-2020.6, 780,000.

2. Completed projects

[1] National Natural Science Foundation of China "Research on the formation and reaction mechanism of AHQ intermediates in the biosynthetic pathway of pyrroloquinoline quinone (21476217)" 2015.01-2018.12 Fund 810,000;

[2] State Tobacco Monopoly Administration Tobacco Industry Tobacco Industry Biotechnology Key Laboratory Project "Research on Tobacco Lutein Biodegradation and Application", key laboratory project, 500,000;

[3] Henan Provincial Natural Science Foundation Project, Molecular basis and catalytic mechanism of complex enzyme synthesis of "pyrroloquinoline quinone", project number: 162300410324, time: 2017.01-2018.12, 100,000;

[4] Henan Provincial Department of Human Resources and Social Security, 2016.01-2018.12, start-up funding for scientific research after studying abroad, 300,000;

[5] National "Twelfth Five-Year" Major New Drug Creation Special Sub-project, "Large-scale Preparation of Biotech Drugs", Project No.: 2012ZX09304009-5, 2012.01-2015.12, 800,000 yuan;

[6] The State Tobacco Monopoly Administration Key Laboratory Project "Technical Research on the Synergy of Compound Heat-resistant Enzymes to Promote the Quality and Fragrance of Reconstituted Tobacco Leaves by Papermaking", Contract No.: 110201503004, Time: 2016.01-2017.12, 1 million;

[7] Henan University Innovative Talent Project, Key Technology for Large-scale Preparation of Food Functional Factor "Pyrroloquinoline Quinone", Project No.: 16HASTIT013, 2016.01-2017.12, 600,000.

Honors:

1.The Shanghai Excellent Doctoral Dissertation Award

2.The Second Prize of National Technological Invention Award

Professional Affiliations :

Member of China Enzyme Engineering Professional Committee